RASolute 309: what clinicians are saying
zoldonrasib plus daraxonrasib in first-line metastatic KRAS G12D-mutated pancreatic adenocarcinoma · NCT07805954 ↗ · Phase 3 · Revolution Medicines, Inc.
The clinicians cited see RASolute 309 as a possible route away from chemotherapy, drawing on earlier doublet activity rather than evidence warranting treatment change. Its position relative to mFOLFIRINOX and nalIRINOX remains unestablished, and hopes for wider access do not confirm availability. Activity and rash observations largely concern earlier studies or broader daraxonrasib use; no results from the trial itself were available in the sources reviewed for this edition.
Created with AI · how we check it
- edition 1
- commentary checked Nov 11, 2026
- 25 verified statements
This edition $750, with MCP access for your AI agent. Get this report
3 findings, and what sits behind each
01. Speakers welcome a chemotherapy-free first-line possibility but await phase 3 confirmation
5 of 10 cited clinicians · 14 statements from 6 speakers in 12 sources, 1 of them a podcast or video · 13 passages
Limitations recorded: 2.
Draws on: The comparison, Secondary endpoints, Primary endpoint: Progression free survival (PFS), Primary endpoint: Overall survival (OS), Population and setting, Safety and tolerability, Design and conduct.
02. One LinkedIn account asks: why use GemNabTAX as the control rather than mFOLFIRINOX or nalIRINOX?
No named clinician · accounts and unnamed speakers · 5 statements from 2 speakers in 3 sources · 3 passages
Limitations recorded: 2.
Draws on: The comparison, Design and conduct, Primary endpoint: Progression free survival (PFS), Primary endpoint: Overall survival (OS), Population and setting.
03. One LinkedIn account hopes for Brazilian study access; a UK account sees progress toward access
1 of 10 cited clinicians · 4 statements from 1 speaker in 4 sources, 2 of them podcasts or videos · 4 passages
Limitations recorded: 2.
Draws on: Design and conduct.
Counts overlap, since one statement can back several findings. They show what the report kept, not how many clinicians agree. The full report includes the interpretations and source links.
Select a finding to see what the full report holds for it. Select a part of the trial to see which findings draw on it.
- Finding 1 of 3
5 of 10 cited clinicians
Speakers welcome a chemotherapy-free first-line possibility but await phase 3 confirmation
14 statements from 6 speakers in 12 sources, 1 of them a podcast or video
- 14
- statements
- 13
- passages
- 12
- sources
- 6
- speakers
What the statements areViews 8Questions and uncertainty 3Clinical experience 0Comparisons 1Restated results and context 2Statement-to-passage links (a passage can back several statements)Supporting a statement 17Giving context 3Recorded with the findingLimitations: 2
10 posts and articles · 1 podcast or video · 1 registry
Draws on: The comparison, Secondary endpoints, Primary endpoint: Progression free survival (PFS), Primary endpoint: Overall survival (OS), Population and setting, Safety and tolerability, Design and conduct.
Thicker lines mean more shared statements. A finding without a line goes beyond the registered design. Counts overlap: one statement can back several findings.
The full report also has 6 findings about other patients, lines of treatment or settings, after these trial findings under “Beyond the trial population”. They are not counted or listed on this page.
Physician · US
Video · Jul 2026
NPI checked · finding 1
A physician considers RASolute-309 one of the most exciting forthcoming studies and is very excited about its potential to improve outcomes for patients with KRAS G12D.
Statements as the report records them, by the speaker's role only. Full statements, speaker names and links to each source are in the report.
Abbreviations (5)
HCP, healthcare professional; MCP, Model Context Protocol, how AI agents read the report; NPI, National Provider Identifier, the US registry number for clinicians; OS, overall survival; PFS, progression-free survival.
The full RASolute 309 report gives each finding its interpretation, the attributed views behind it, counterviews, limits and the verified statements, each linked to the original. One report in the catalog, IDeate-Lung01, is free in full, so you can see what a paid report holds before you buy: read the free IDeate-Lung01 report.
What do clinicians need to see in RASolute 309’s PFS and OS results before using zoldonrasib plus daraxonrasib as a chemotherapy-free alternative to first-line gemcitabine plus nab-paclitaxel for metastatic KRAS G12D-mutated pancreatic adenocarcinoma?
From finding F1 (14 statements from 6 speakers in 12 sources). The report shows what clinicians said and the sources behind it; it does not settle the question.
By the numbers
- 43commentary sources screened
- 25sources cited by verified statements
- 17named in screened sources
- 17speakers cited in the report
- 15cited speakers with a verified identity
10 cited clinicians, speakers with a confirmed clinical role, of them 10 physicians. By role and specialty:
- 6 physician, Medical oncology
- 4 physician, specialty not confirmed
Also in the sources: 3 organizational or shared accounts, not counted as people.
- 25verified statements, each linked to its source
- 8of them from speakers with a confirmed clinical role
- 3findings
Built by AI from public clinician commentary, checked by automated review; every statement links to its source.
A cited clinician is a cited speaker whose clinical role the NPI registry or their own institution's staff page confirms; a role a source only states is not counted. A verified identity says who a speaker is, with or without such a role. Physicians are clinicians whose confirmed role is a physician's.
Counts show what the report kept, not how many clinicians hold a view. Size is set by the verified statements; Standard and Deep need 5 or more cited clinicians. Statements from sponsors, hosts and organisations are labelled and count apart.
What's inside
| Section | Items | Access |
|---|---|---|
| Findings with interpretation, counterviews and limits | 3 | Titles free |
| Detailed analysis | 11 sections | Paid |
| Verified statements with short source quotes and links | 25 | Paid |
| Who said each statement: the cited speakers | 17 | Every edition |
| Speakers with a clinical role confirmed by the NPI registry or a staff page | 10 | Every edition |
| Speakers with verified IDs as data (NPI, ORCID, staff page) | 15 | Every edition |
| CMS-reported financial relationships (Open Payments, by company) for NPI-linked speakers | Included | Every edition |
| Trial aspects mapped | 8 | Free |
| Sources with links | 25 | Counts free |
| MCP access for your AI agent, same license key | Included | Every edition |
Every edition names who said each statement, with MCP access for your AI agent. Each verified speaker comes with their verified IDs (NPI, ORCID, staff page) so your team can check each attribution. Allowed: advisory boards, scientific exchange and finding investigators, under your own compliance process. Not allowed: sales or marketing to clinicians.
Trial aspects
8 discussed · 0 no commentary found · 0 assessment incomplete| Aspect | Statements | Sources |
|---|---|---|
| Primary endpoint: Progression free survival (PFS) | 2 | 1 |
| Primary endpoint: Overall survival (OS) | 2 | 1 |
| Secondary endpoints | 3 | 4 |
| Population and setting | 2 | 2 |
| The comparisonThe registered arms and what clinicians said about how they compare. | 10 | 10 |
| Safety and tolerability | 2 | 2 |
| Design and conduct | 4 | 3 |
| Other public accounts' launch and pipeline interpretations | 4 | 3 |
Discussed means at least one verified statement addresses the aspect, not that every question in it is covered: gaps inside a discussed aspect are listed under Scope and limits, and the full report gives each aspect its own limitations. No commentary found means none in the sources read. Assessment incomplete marks an aspect with no statement found while known source limits apply.
Sources
25 verified statements from 25 cited sources. A video or podcast is one source but often carries many statements, so the table counts statements, not just posts.
| Channel | Statements | Cited | Screened | |
|---|---|---|---|---|
| Video & audio · 7 statements · 28%from 6 videos and episodes · about 1 per source | ||||
| YouTube | 7 | 5 | 5 | |
| Podcasts | 0 | 1 | 1 | |
| Posts · 17 statements · 68%from 18 posts · about 0.9 per source | ||||
| X threads | 6 | 12 | 28 | |
| LinkedIn posts | 11 | 6 | 7 | |
| Bluesky threads | 0 | 0 | 2 | |
| Primary sources · 1 statement · 4%cited for context, not screened · from 1 source · about 1 per source | ||||
| Registry | 1 | 1 | — | |
Screened: found and read for this trial. Cited: backs at least one statement. Bar = statements; a statement drawn from two sources counts half to each. How we sourced and checked this
max 24 / quarter
- Screened window
- Apr 16, 2026 → Oct 26, 2026
- Cited window
- Apr 16, 2026 → Oct 16, 2026
- Retrieved
- Nov 11, 2026
The trial
from ClinicalTrials.gov- Title
- A Phase 3, Randomized, Open-Label Study of Zoldonrasib (RMC-9805) Plus Daraxonrasib (RMC-6236) Versus Gemcitabine and Nab-Paclitaxel as First-Line Treatment in Patients With Metastatic KRAS G12D-Mutated Pancreatic Adenocarcinoma
- Registry
- NCT07805954
- Study IDs
- RMC-9805-309
- Sponsor
- Revolution Medicines, Inc.
- Design
- Phase 3 · Interventional, randomized, parallel
- Status
- Recruiting
- Enrollment
- 400 estimated
- Registered
- 2026-09-08
- Start
- 2026-08-28 actual
- Primary completion
- 2029-03 estimated
- Primary endpoints
- Progression free survival (PFS)
- Overall survival (OS)
- Interventions
- 4 registered
More on: Pancreatic cancer
Scope and limits
This report does not judge efficacy, estimate HCP prevalence or consensus or give treatment advice.
- Discussion that does not name the trial may be missing from this edition.
- 1 clinician view in the sources used in this report is not yet captured as evidence in this edition.
- 56 statements in the sources reviewed for this edition are about other patients or topics, or only mention the trial, and are not counted.
- Further source limits: 24 sources about other trials or topics are not included.
- The sources reviewed for this edition are a selected public-discussion sample, not a representative survey of HCP opinion; repeated posts and relays do not establish independent agreement.
Show all 9 known gaps +Fewer −
- Some passages cannot be assigned to a named speaker. Participant lists, professional profiles and recurring transcript labels do not resolve those passages.
- Much of the efficacy, toxicity, patient-reported-outcome and practical-management discussion concerns pretreated doublet cohorts or daraxonrasib in other settings. Those observations do not establish outcomes for the first-line RASolute 309 combination.
- No exact-trial results publication or protocol document was available in the reviewed material. Regulatory and access statements are attributed to their sources and do not independently confirm approval, reimbursement or local availability of the doublet.
- Several comments are personal experience, preclinical interpretation, cross-study comparison or prospective expectation. Unspecified cohorts and slightly differing numerical accounts prevent treating them as a single comparative dataset.
How reports are built and checked: Methods.
Editions and corrections
Routine maintenance: 1 fix (text)
None of these changed a statement, finding or source.
- Nov 11, 2026 UTCA summary sentence now uses the wording of the finding it summarizes.
Last checked for new commentary Nov 11, 2026 UTC. No changes. Follow new editions and changes in this report's change feed (JSON Feed), or the catalog's. How versions and corrections work.
Cite this report
Erudio Health. RASolute 309 (NCT07805954): HCP commentary report. Edition 1, v1.0.0. Accepted Nov 11, 2026. https://www.erudio.com/reports/rasolute-309-nct07805954
For your AI agent
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Help me decide whether to buy the Erudio report "RASolute 309" (NCT07805954), and buy it for me if I ask. Erudio reports cover what clinicians say in public about one clinical trial, with every verified statement linked to its source.
1. Use the free Erudio MCP server at https://mcp.erudio.com/free; it needs no sign-in. Nothing needs installing: if it is not connected in this app and you can make HTTP requests, call it directly with JSON-RPC POSTs to that URL (initialize, then tools/call), sending "Accept: application/json, text/event-stream". Call get_report_card with slug "rasolute-309-nct07805954". If you cannot make requests, read https://www.erudio.com/reports/rasolute-309-nct07805954.md instead.
2. In a few lines, tell me what the report covers: its findings, its verified statements and sources, its evidence window, what it leaves out, and the price of each product (offer). Then ask what I need it for, and say plainly whether this report answers it.
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4. Once it is paid, call get_order with the status_url: it returns my license key. Then use the Erudio MCP server at https://mcp.erudio.com/mcp with the header "Authorization: Bearer <key>". Call read_report with report_id NCT07805954 and sections ["all"], and summarize the findings for me with their sources. The full report can be long: save the response to a file and work from it rather than printing it. If you cannot, read sections ["narratives"] first, the executive summary and analysis.
When you tell me what clinicians said, give each view as theirs, with its source. Counts are the sources the report kept, not the share of clinicians who agree. Reports are not medical advice.
Keep the key private to my organization.Or read the record directly: JSON, Markdown or MCP
curl https://www.erudio.com/reports/rasolute-309-nct07805954.json
curl https://www.erudio.com/reports/rasolute-309-nct07805954.md
# MCP, no sign-in (https://mcp.erudio.com/free)
get_report_card({ "slug": "rasolute-309-nct07805954" })release 202ec535a94bcf0a65ed95069c537c9369a97be42c522bfd9715e4f2d407ff9f
Questions
How much does the RASolute 309 report cost?
One edition costs $750 (Focused · 25 verified statements · 8 from 10 confirmed clinicians). With updates: 3 months $1,300, 6 months $1,900, 12 months $2,600. Subscriptions are prepaid, and the price is fixed for the term you buy, even if a new edition moves the trial up a size. Nothing renews automatically: a new term is bought at the price then current.
What does the RASolute 309 report cover?
25 statements from 25 sources (1 podcast, 5 videos, 18 posts, 1 registry record), 8 of them from 10 confirmed clinicians, each linked to its source. Commentary checked Nov 11, 2026. The report separates what clinicians said from what primary sources establish; it does not judge efficacy or estimate consensus.
Can my AI agent read or buy the RASolute 309 report?
Yes. On https://mcp.erudio.com/free, with no sign-in, get_report_card({ "slug": "rasolute-309-nct07805954" }) previews it and create_order({ "report": "rasolute-309-nct07805954", "product": "edition", "buyer_email": "<work email>" }) orders it. Once paid, the license key reads it with read_report on https://mcp.erudio.com/mcp. Connect your AI client.
How current is the RASolute 309 report?
Edition 1 (version 1.0.0), accepted Nov 11, 2026 UTC; last checked for new commentary Nov 11, 2026 UTC. Your plan includes every new edition published during its term. We automatically check subscribed trials for new commentary every week.