RMC-GI-102

An aspect marked incomplete is a question the public commentary did not let us answer. We show it rather than hide it.

Screened window

Jun 10, 2024 → Sep 18, 2026

Cited window

Dec 18, 2024 → Sep 18, 2026

Retrieved

Oct 29, 2026

Title

A Platform Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

Registry

NCT06445062

Study IDs

RMC-GI-102

Sponsor

Revolution Medicines, Inc.

Design

Phase 1/Phase 2 · Interventional, non randomized, parallel

Status

Recruiting

Enrollment

1,130 estimated

Start

2024-05-24 actual

Primary completion

2028-09-30 estimated

Primary endpoint

Adverse events (Subprotocols A-F)

Interventions

9 registered

This report does not judge efficacy, estimate HCP prevalence or consensus or give treatment advice.

• –Discussion that does not name the trial may be missing from this edition.
• –Some clinician views in the sources used in this report are not yet captured as evidence in this edition.
• –Some passages in the sources used in this report were not fully assessed for clinician views, so a view there may be missing from this edition.
• –17 statements in the sources reviewed for this edition are about other patients or topics, or only mention the trial, and are not counted.
• –Further source limits: discussion that describes the trial without naming it may be incomplete; some discussion that describes the trial without naming it may be missing; sources about other trials are not included.
• –The sources reviewed for this edition do not represent all HCPs or all public discussion. Unnamed references and different spellings may be missing.
• –One first-line daraxonrasib-monotherapy passage was not fully assessed, so additional views on that alternative may be absent.
• –Not every author's identity or clinical role is confirmed. Source-described credentials do not establish a verified clinical role, and channel ownership does not identify an anonymous speaker.
• –No protocol document or complete results publication is included. Detailed methods, endpoint ascertainment and mature comparative outcomes cannot be established from the commentary alone.
• –Regulatory coverage is incomplete, and exact labels for RMC-6236 and the mFOLFOX6 regimen are not included. Approval descriptions remain attributed to the announcements.
• –Most substantive discussion concerns PDAC. The platform's CRC cohorts and several registry-listed endpoints receive little or no specific commentary.
• –Not yet captured in this edition: a view on first-line RAS(ON) inhibitor monotherapy as an alternative treatment for metastatic pancreatic cancer.
• –Not yet captured in this edition: a view on first-line daraxonrasib monotherapy as an alternative treatment.

How reports are built and checked: Methods.

Last checked for new commentary Oct 29, 2026. A new or changed finding gets a new version number; added evidence alone is a smaller update.

Paste this into ChatGPT, Claude, Microsoft Copilot or your own agent. It previews this report through the free Erudio MCP server, tells you whether it answers your question, and orders it if you ask. Some agents ask you to confirm pasted instructions before acting; that is expected.

Help me decide whether to buy the Erudio report "RMC-GI-102" (NCT06445062), and buy it for me if I ask. Erudio reports cover what clinicians say in public about one clinical trial, with every verified statement linked to its source.

1. Use the free Erudio MCP server at https://mcp.erudio.com/free; it needs no sign-in. Nothing needs installing: if it is not connected in this app and you can make HTTP requests, call it directly with JSON-RPC POSTs to that URL (initialize, then tools/call), sending "Accept: application/json, text/event-stream". Call get_report_card with slug "rmc-gi-102-06445062". If you cannot make requests, read https://www.erudio.com/reports/rmc-gi-102-nct06445062.md instead.
2. In a few lines, tell me what the report covers: its findings, its verified statements and sources, its evidence window, what it leaves out, and the price of each product (offer). Then ask what I need it for, and say plainly whether this report answers it.
3. If I want it, ask for my work email and the product: the current edition, or 3, 6 or 12 months of weekly updates. Call create_order with report "NCT06445062", that product and email, then show me the quote and the checkout_url to pay by card. If you have a payment client for HTTP 402 payments and I agree, you can pay the pay_url instead. Nothing is charged until one is paid.
4. Once it is paid, call get_order with the status_url: it returns my license key. Then use the Erudio MCP server at https://mcp.erudio.com/mcp with the header "Authorization: Bearer <key>". Call read_report with report_id erudio-nct06445062 and sections ["all"], and summarize the findings for me with their sources. The full report is large (about 500 KB): save the response to a file and work from it rather than printing it. If you cannot, read sections ["narratives"] first, the executive summary and analysis.

When you tell me what clinicians said, give each view as theirs, with its source. Counts are the sources the report kept, not the share of clinicians who agree. Reports are not medical advice.
Keep the key private to my organization.

curl https://www.erudio.com/reports/rmc-gi-102-nct06445062.json
curl https://www.erudio.com/reports/rmc-gi-102-nct06445062.md

# MCP, no sign-in (https://mcp.erudio.com/free)
get_report_card({ "slug": "rmc-gi-102-06445062" })