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Clinical trial · no report yet · Phase 2

ATEMPT 2.0

ATEMPT 2.0: Adjuvant T-DM1 vs TH

We haven't built a report for this trial yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.

Preliminary discovery

Commentary in our index that names this trial so far

Podcasts, YouTube videos and X posts we have indexed. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build.

ChannelFound
X threads2
Bluesky threads1

The trial

ClinicalTrials.gov
Official title
A Randomized Phase II Trial of Adjuvant Trastuzumab Emtansine (T-DM1) Followed by Subcutaneous Trastuzumab Versus Paclitaxel in Combination With Subcutaneous Trastuzumab for Stage I HER2-positive Breast Cancer (ATEMPT 2.0)
Phase
Phase 2
Status
Recruiting
Conditions
Breast Cancer; HER2-positive Breast Cancer
Interventions
trastuzumab-emtansine; Trastuzumab SC; Paclitaxel
Arms
  • Arm A. T-DM1 followed by Trastuzumab SC · Experimental
  • Arm B: Paclitaxel with Trastuzumab SC, followed by Trastuzumab SC alone · Experimental
Enrollment
500 (estimated)
Primary outcomes
  • Incidence of clinically relevant toxicities (CRT)
  • Disease Free Survival (DFS)
Sponsor
Dana-Farber Cancer Institute with Genentech, Inc.
Start
Jun 16, 2021
Primary completion
Nov 1, 2028 (estimated)
Results posted
No
Registry record
NCT04893109 · updated Aug 19, 2026