Clinical trial · no report yet · Phase 2

CAO/ARO/AIO-12 trial: what clinicians have said so far

Induction Chemotherapy Before or After Preoperative Chemoradiotherapy and Surgery for Locally Advanced Rectal Cancer

NCT02363374 ↗
Completed
Prof. Dr. med. Claus Rödel
Deep size, estimated: 301+ verified statements

We haven't built an HCP commentary report on CAO/ARO/AIO-12 (locally advanced rectal cancer) yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.

Indexed commentary on CAO/ARO/AIO-12 so far

Podcasts, YouTube videos and X posts we have indexed that name the trial. It is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this.

Indexed so far
20 posts on X
2 podcast episodes

Indexed todayTypical once built

The trial

ClinicalTrials.gov

Official title: Induction Chemotherapy Before or After Preoperative Chemoradiotherapy and Surgery for Locally Advanced Rectal Cancer: A Randomized Phase II Trial of the German Rectal Cancer Study Group
Phase: Phase 2
Status: Completed
Conditions: Rectal Neoplasms; Rectal Cancer Stage II; Rectal Cancer Stage III
Interventions: Induction Chemotherapy arm A; Radiation arm A; Radiation arm B; Chemotherapy arm B; Surgery
Arms: Arm A: Chemotherapy -> Chemoradiotherapy · Active comparator
Arm B: Chemoradiotherapy -> Chemotherapy · Experimental
Enrollment: 311
Primary outcomes: Number of patients with pathological complete response (pCR), i.e. ypT0N0.
Sponsor: Prof. Dr. med. Claus Rödel with Johann Wolfgang Goethe University Hospital, Deutsche Krebshilfe e.V., Bonn (Germany)
Start: Mar 25, 2015
Primary completion: Sep 2018
Results posted: No
Registry record: NCT02363374 · updated Dec 4, 2023

Publications

linked from the registry

Sauer R, Becker H, Hohenberger W, Rodel C, Wittekind C, Fietkau R, Martus P, Tschmelitsch J, Hager E, Hess CF, Karstens JH, Liersch T, Schmidberger H, Raab R; German Rectal Cancer Study Group. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004 Oct 21;351(17):1731-40. doi: 10.1056/NEJMoa040694. PubMed 15496622
Sauer R, Liersch T, Merkel S, Fietkau R, Hohenberger W, Hess C, Becker H, Raab HR, Villanueva MT, Witzigmann H, Wittekind C, Beissbarth T, Rodel C. Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years. J Clin Oncol. 2012 Jun 1;30(16):1926-33. doi: 10.1200/JCO.2011.40.1836. Epub 2012 Apr 23. PubMed 22529255
Rodel C, Liersch T, Becker H, Fietkau R, Hohenberger W, Hothorn T, Graeven U, Arnold D, Lang-Welzenbach M, Raab HR, Sulberg H, Wittekind C, Potapov S, Staib L, Hess C, Weigang-Kohler K, Grabenbauer GG, Hoffmanns H, Lindemann F, Schlenska-Lange A, Folprecht G, Sauer R; German Rectal Cancer Study Group. Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial. Lancet Oncol. 2012 Jul;13(7):679-87. doi: 10.1016/S1470-2045(12)70187-0. Epub 2012 May 23. PubMed 22627104
Diefenhardt M, Fokas E, Kosmala R, Polat B, Germer CT, Schlenska-Lange A, Kuhnt T, Ghadimi M, Rieken S, Wiegering A, Schwarzbach M, Fleischmann M, Grutzmann R, Ott OJ, Martus P, Konigsrainer A, Zips D, Hofheinz RD, Gani C, Rodel C. Organ Preservation and Quality of Life After Total Neoadjuvant Treatment in Rectal Cancer. JAMA Netw Open. 2026 Oct 1;9(10):e2639063. doi: 10.1001/jamanetworkopen.2026.39063. PubMed 42879156
Diefenhardt M, Fleischmann M, Martin D, Hofheinz RD, Piso P, Germer CT, Hambsch P, Grutzmann R, Kirste S, Schlenska-Lange A, Ghadimi M, Rodel C, Fokas E; German Rectal Cancer Study Group. Clinical outcome after total neoadjuvant treatment (CAO/ARO/AIO-12) versus intensified neoadjuvant and adjuvant treatment (CAO/ARO/AIO-04) a comparison between two multicenter randomized phase II/III trials. Radiother Oncol. 2023 Feb;179:109455. doi: 10.1016/j.radonc.2022.109455. Epub 2022 Dec 23. PubMed 36572280
Fokas E, Schlenska-Lange A, Polat B, Klautke G, Grabenbauer GG, Fietkau R, Kuhnt T, Staib L, Brunner T, Grosu AL, Kirste S, Jacobasch L, Allgauer M, Flentje M, Germer CT, Grutzmann R, Hildebrandt G, Schwarzbach M, Bechstein WO, Sulberg H, Friede T, Gaedcke J, Ghadimi M, Hofheinz RD, Rodel C; German Rectal Cancer Study Group. Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Patients With Locally Advanced Rectal Cancer: Long-term Results of the CAO/ARO/AIO-12 Randomized Clinical Trial. JAMA Oncol. 2022 Jan 1;8(1):e215445. doi: 10.1001/jamaoncol.2021.5445. Epub 2022 Jan 20. PubMed 34792531

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Indexed commentary on CAO/ARO/AIO-12 so far

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The trial

Publications