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Clinical trial · no report yet · Phase 3

CARE1

CARE1 Pragmatic Clinical Trial

We haven't built a report for this trial yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.

Preliminary discovery

Commentary in our index that names this trial so far

Podcasts, YouTube videos and X posts we have indexed. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build.

ChannelFound
X threads24
YouTube9
Podcasts5
Bluesky threads1
X videos1

The trial

ClinicalTrials.gov
Official title
First Line Randomised Study Platform to Optimize Treatment in Patients With Metastatic Renal Cell Carcinoma
Phase
Phase 3
Status
Recruiting
Conditions
Metastatic Kidney Cancer; Metastatic Kidney Carcinoma
Interventions
Nivolumab; Ipilimumab; Pembrolizumab; Cabozantinib; Axitinib; Lenvatinib
Arms
  • Arm A: ICI - ICI Combination · Other
  • Arm B: VEGFR-TKI- ICI arm (axitinib + pembrolizumab) · Other
Enrollment
1,250 (estimated)
Primary outcomes
  • Overall Survival (OS).
Sponsor
Gustave Roussy, Cancer Campus, Grand Paris with European Commission, CRIS Cancer Foundation, National Cancer Institute, France, Rennes University Hospital, University Hospital, Essen, Fundació Privada Institut d'Investigació Oncològica de Vall d'Hebron, The Netherlands Cancer Institute, Servicio Madrileño de Salud, Madrid, Spain, Hospital Universitario 12 de Octubre, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Medical University of Vienna, FAKULTNI NEMOCNICE OLOMOUC, International Kidney Cancer Coalition, Association pour la Recherche sur les Tumeurs du Rein, Resilience, PRIMAA, Queen Mary University of London
Start
Apr 12, 2024
Primary completion
May 5, 2032 (estimated)
Results posted
No
Registry record
NCT06364631 · updated Jan 16, 2025