CheckMate 77T

Automated, Oct 29, 2026. Not an Erudio report: no source links. Not medical advice.

The commentary discusses CheckMate 77T’s perioperative nivolumab and chemotherapy approach for resectable NSCLC, its comparison with neoadjuvant-only treatment in CheckMate 816, and exploratory analyses by nodal status and biomarkers, including ctDNA clearance and minimal residual disease. Speakers raise whether perioperative treatment offers an advantage over neoadjuvant treatment alone, whether ctDNA can serve as a surrogate marker, and whether available evidence resolves the debate over chemotherapy-cycle selection. Discussion also covers identifying patient and disease characteristics that may inform treatment selection.

Official title

A Phase 3, Randomized, Double-blind Study of Neoadjuvant Chemotherapy Plus Nivolumab Versus Neoadjuvant Chemotherapy Plus Placebo, Followed by Surgical Resection and Adjuvant Treatment With Nivolumab or Placebo for Participants With Resectable Stage II-IIIB Non-small Cell Lung Cancer

Phase

Phase 3

Status

Active, not recruiting

Conditions

Carcinoma, Non-Small-Cell Lung

Interventions

Nivolumab; Carboplatin; Cisplatin; Paclitaxel; Pemetrexed; Placebo; Docetaxel

Arms

• Neoadj. Nivo+ Pt-based Doublet Chemo followed by Adj. Nivo · Experimental
• Neoadj. Plac. + Pt-based Doublet Chemo followed by Adj.Plac. · Placebo comparator

Enrollment

461

Primary outcomes

• Event-Free Survival (EFS) by BICR

Sponsor

Bristol-Myers Squibb

Start

Nov 5, 2019

Primary completion

Jul 26, 2023

Results posted

Yes

Registry record

NCT04025879 · updated Aug 26, 2026

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