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Clinical trial · no report yet · Phase 2
CRESTONE
Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors
- NCT04383210 ↗
- Terminated
- Elevation Oncology
- Focused
We haven't built an HCP commentary report on CRESTONE (seribantumab in Locally Advanced Solid Tumor) yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.
Indexed commentary on CRESTONE so far
Podcasts, YouTube videos and X posts we have indexed that name the trial. It is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this.
| Channel | Indexed | |
|---|---|---|
| X threads | 4 | |
| Podcasts | 3 | |
| YouTube | 2 |
The trial
ClinicalTrials.gov- Official title
- CRESTONE: A Phase 2 Study of Seribantumab in Adult Patients With Neuregulin-1 (NRG1) Fusion Positive Locally Advanced or Metastatic Solid Tumors
- Phase
- Phase 2
- Status
- Terminated
- Conditions
- Locally Advanced Solid Tumor; Metastatic Solid Tumor; Pancreatic Cancer; Lung Cancer; Head and Neck Cancer; Breast Cancer; Kidney Cancer; Colorectal Cancer; Bladder Cancer; Ovarian Cancer; Sarcoma; Gallbladder Cancer; Bile Duct Cancer; Esophageal Cancer; Uterine Cancer; Cholangiocarcinoma; Prostate Cancer
- Interventions
- Seribantumab
- Arms
- Cohort 1 · Experimental
- Cohort 2 · Experimental
- Cohort 3 · Experimental
- Enrollment
- 54
- Primary outcomes
- Objective Response Rate
- Sponsor
- Elevation Oncology
- Start
- Sep 29, 2020
- Primary completion
- Feb 28, 2024
- Results posted
- Yes
- Registry record
- NCT04383210 · updated Apr 3, 2025
Publications
linked from the registry- Patil T, Lin JJ, Cheema PK, Carrizosa DR, Burkard ME, Elamin YY, Desai J, Patel JD, Nagasaka M, Reckamp KL, Waqar SN, Bauman JR, Schram AM, Gadgeel SM, Ma PC, Konduri K, Nguyen D, Misleh J, Bleeker J, Weiss M, Thavaneswaran S, Haura EB, Deegan M, Kaufman J, Srivastava J, Jansen VM, Liu SV. CRESTONE: A Phase II Study of the Efficacy and Safety of the HER3 Monoclonal Antibody, Seribantumab, in Solid Tumors With Neuregulin-1 (NRG1) Fusions. JCO Precis Oncol. 2025 Aug;9:e2500221. doi: 10.1200/PO-25-00221. Epub 2025 Dec 22. PubMed 41428976