Clinical trial · no report yet · Phase 2
Decrescendo
De-escalation Adjuvant Chemo in HER2+/ER-/node-neg Early BC Patients Who Achieved PCR After Neoadjuvant Chemo & Dual HER2 Blockade
- NCT04675827 ↗
- Terminated
- Jules Bordet Institute
- Standard
We haven't built a report for this trial yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.
Preliminary discovery
Commentary in our index that names this trial so far
Podcasts, YouTube videos and X posts we have indexed. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build.
| Channel | Found | |
|---|---|---|
| YouTube | 7 | |
| X threads | 6 | |
| Podcasts | 4 | |
| Bluesky threads | 1 |
The trial
ClinicalTrials.gov- Official title
- De-Escalation of Adjuvant Chemotherapy in HER2-positive, Estrogen Receptor-negative, Node-negative Early Breast Cancer Patients Who Achieved Pathological Complete Response After Neoadjuvant Chemotherapy and Dual HER2 Blockade
- Phase
- Phase 2
- Status
- Terminated
- Conditions
- HER2-positive Breast Cancer; ER-Negative Breast Cancer; PR-Negative Breast Cancer; Node-negative Breast Cancer
- Interventions
- Pertuzumab and tratuzumab fixed dose combination; Trastuzumab emtansine
- Arms
- RCB = 0 · Experimental
- RCB > 0 · Experimental
- Enrollment
- 139
- Primary outcomes
- 3-year RFS in HER2-enriched subjects who achieve a pCR
- Sponsor
- Jules Bordet Institute with Breast International Group, Hoffmann-La Roche, International Drug Development Institute, Institut Curie
- Start
- Jan 17, 2022
- Primary completion
- Nov 26, 2024
- Results posted
- No
- Registry record
- NCT04675827 · updated Dec 4, 2024
Publications
linked from the registry- Boman C, Tranchell C, Liu X, Eriksson Bergman L, Toli MA, Bergh J, Foukakis T, Matikas A. Prognosis After Pathologic Complete Response to Neoadjuvant Therapy in Early-Stage Breast Cancer: A Population-Based Study. J Natl Compr Canc Netw. 2025 Mar 12;23(4):e247093. doi: 10.6004/jnccn.2024.7093. PubMed 40073831