HELIX-1
mFOLFIRINOX Followed by Hepatic Arterial Infusion of Floxuridine and Dexamethasone With Systemic mFOLFIRI for Unresectable Liver-dominant Intrahepatic Cholangiocarcinoma
- NCT04251715 ↗
- Terminated
- OHSU Knight Cancer Institute
- Focused
We haven't built an HCP commentary report on HELIX-1 (mFOLFIRINOX plus floxuridine plus dexamethasone plus mFOLFIRI in first-line unresectable liver-dominant intrahepatic cholangiocarcinoma) yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.
Indexed commentary on HELIX-1 so far
Podcasts, YouTube videos and X posts we have indexed that name the trial. It is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this.
| Channel | Indexed | |
|---|---|---|
| X threads | 5 |
The trial
ClinicalTrials.gov- Official title
- A Phase II Study of Induction Systemic mFOLFIRINOX Followed by Hepatic Arterial Infusion of Floxuridine and Dexamethasone Given Concurrently With Systemic mFOLFIRI as a First-Line Therapy in Patients With Unresectable Liver-Dominant Intrahepatic Cholangiocarcinoma
- Phase
- Phase 2
- Status
- Terminated
- Conditions
- Liver and Intrahepatic Bile Duct Carcinoma; Stage III Intrahepatic Cholangiocarcinoma AJCC v8; Stage IIIA Intrahepatic Cholangiocarcinoma AJCC v8; Stage IIIB Intrahepatic Cholangiocarcinoma AJCC v8; Stage IV Intrahepatic Cholangiocarcinoma AJCC v8; Unresectable Intrahepatic Cholangiocarcinoma
- Interventions
- Dexamethasone; Floxuridine; Implanted Medical Device; Irinotecan; Leucovorin; Oxaliplatin; Quality-of-Life Assessment
- Arms
- mFOLFIRINOX, Floxuridine-DEX, mFOLFIRI · Experimental
- Enrollment
- 5
- Primary outcomes
- Frequency of Abnormal Liver Function
- Disease Control Rate (DCR) - During HAI+SYS
- Sponsor
- OHSU Knight Cancer Institute with Oregon Health and Science University
- Start
- Apr 28, 2021
- Primary completion
- Mar 20, 2024
- Results posted
- Yes
- Registry record
- NCT04251715 · updated Jun 25, 2026
Publications
linked from the registry- Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004 Aug;240(2):205-13. doi: 10.1097/01.sla.0000133083.54934.ae. PubMed 15273542
- Blair AB, Alobuia WM, Palta M, Raman SS, Levine MH, Benson AB 3rd, D'Angelica MI, Cloyd JM. Locoregional Treatment Options for Locally Advanced Intrahepatic Cholangiocarcinoma. J Natl Compr Canc Netw. 2025 Aug 14;23(9):e257085. doi: 10.6004/jnccn.2025.7085. PubMed 40812353