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Clinical trial · no report yet · Phase 3
HORIZON 1
A Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Participants With Locally Advanced, Unresectable, Stage III Non-Small Cell Lung Cancer (NSCLC)
- NCT05170204 ↗
- Active, not recruiting
- Hoffmann-La Roche
- Focused
We haven't built an HCP commentary report on HORIZON 1 (alectinib; entrectinib in unresectable stage III non-small cell lung cancer) yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.
Indexed commentary on HORIZON 1 so far
Podcasts, YouTube videos and X posts we have indexed that name the trial. It is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this.
| Channel | Indexed | |
|---|---|---|
| YouTube | 4 | |
| X threads | 3 | |
| Podcasts | 2 |
The trial
ClinicalTrials.gov- Official title
- A Phase I-III, Multicenter Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Patients Selected According to Biomarker Status, With Locally Advanced, Unresectable, Stage III Non-Small Cell Lung Cancer
- Phase
- Phase 3
- Status
- Active, not recruiting
- Conditions
- Non-Small Cell Lung Cancer
- Interventions
- Alectinib; Entrectinib; Durvalumab
- Arms
- Cohort A1: Anaplastic Lymphoma Kinase (ALK)-positive (Alectinib Arm) · Experimental
- Cohort A1: ALK-positive (Durvalumab Arm) · Active comparator
- Cohort A2: ROS Proto-oncogene 1 (ROS 1)-positive (Entrectinib Arm) · Experimental
- Cohort A2: ROS 1-positive (Durvalumab Arm) · Active comparator
- Enrollment
- 68
- Primary outcomes
- Progression-free Survival (PFS), as Determined by Blinded Independent Central Review (BICR) per Response Evaluation Criterial in Solid Tumors Version 1.1 (RECIST V1.1)
- Sponsor
- Hoffmann-La Roche
- Start
- Nov 1, 2022
- Primary completion
- Jun 16, 2030 (estimated)
- Results posted
- No
- Registry record
- NCT05170204 · updated Aug 5, 2026