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Clinical trial · no report yet · Phase 3

MAGNETISMM-5

A Study to Learn About the Study Medicine Elranatamab Alone and With Daratumumab in People With Multiple Myeloma Who Have Received Other Treatments

We haven't built a report for this trial yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.

Preliminary discovery

Commentary in our index that names this trial so far

Podcasts, YouTube videos and X posts we have indexed. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build.

ChannelFound
X threads15
YouTube9
Podcasts2

The trial

ClinicalTrials.gov
Official title
AN OPEN-LABEL, 3-ARM, MULTICENTER, RANDOMIZED PHASE 3 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ELRANATAMAB (PF-06863135) MONOTHERAPY AND ELRANATAMAB + DARATUMUMAB VERSUS DARATUMUMAB + POMALIDOMIDE + DEXAMETHASONE IN PARTICIPANTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA WHO HAVE RECEIVED AT LEAST 1 PRIOR LINE OF THERAPY INCLUDING LENALIDOMIDE AND A PROTEASOME INHIBITOR
Phase
Phase 3
Status
Recruiting
Conditions
Multiple Myeloma
Interventions
Elranatamab; Daratumumab; Pomalidomide; Dexamethasone
Arms
  • Part 1 Safety Lead-In Dose Escalation: Elranatamab + Daratumumab · Experimental
  • Part 2 Randomized Arm A: Elranatamab · Experimental
  • Part 2 Randomized Arm B: Elranatamab + Daratumumab · Experimental
  • Part 2 Randomized Arm C: Daratumumab + Pomalidomide + Dexamethasone · Active comparator
  • Part 3 Arm D: Elranatamab · Experimental
  • Part 3 Arm E: Elranatamab + Daratumumab · Experimental
Enrollment
893 (estimated)
Primary outcomes
  • Part 1 Safety Lead-In: Incidence of dose limiting toxicities
  • Part 2 Randomized: Progression free survival per International Myeloma Working Group criteria
  • Part 3: Frequency of treatment-emergent adverse events
Sponsor
Pfizer
Start
Oct 4, 2021
Primary completion
Feb 26, 2026
Results posted
No
Registry record
NCT05020236 · updated Aug 24, 2026