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Clinical trial · no report yet · Phase 2
MATISSE
Neo-adjuvant Nivolumab or Nivolumab With Ipilimumab in Advanced Cutaneous Squamous Cell Carcinoma Prior to Surgery
- NCT04620200 ↗
- Completed
- The Netherlands Cancer Institute
- Standard
We haven't built an HCP commentary report on MATISSE (nivolumab plus ipilimumab; nivolumab in resectable advanced cutaneous squamous cell carcinoma) yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.
Indexed commentary on MATISSE so far
Podcasts, YouTube videos and X posts we have indexed that name the trial. It is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this.
| Channel | Indexed | |
|---|---|---|
| Podcasts | 10 | |
| X threads | 6 | |
| YouTube | 2 |
The trial
ClinicalTrials.gov- Official title
- Neo-adjuvant Nivolumab or Nivolumab With Ipilimumab in Advanced Cutaneous Squamous Cell Carcinoma Patients Prior to Standard of Care Surgery; the MATISSE Trial
- Phase
- Phase 2
- Status
- Completed
- Conditions
- Cutaneous Squamous Cell Carcinoma
- Interventions
- Nivolumab; Ipilimumab
- Arms
- ARM A · Experimental
- ARM B · Experimental
- Enrollment
- 50
- Primary outcomes
- Histopathological response rate at standard of care
- Sponsor
- The Netherlands Cancer Institute
- Start
- Aug 11, 2020
- Primary completion
- Jan 7, 2025
- Results posted
- No
- Registry record
- NCT04620200 · updated Aug 11, 2025
Publications
linked from the registry- Breukers SE, Traets JJH, van Dijk SW, Ostos MM, Fraterman I, Crommelin RD, van der Hulst H, Qiao X, Boere T, van de Poll-Franse LV, Retel V, van der Noort V, Vos JL, Toppenberg AGL, van der Heijden M, Missale F, Balm F, van den Brekel M, Dirven R, Karakullukcu MB, Karssemakers L, Klop WMC, Lohuis PJFM, Schreuder WH, Smeele LE, van der Velden LA, Plasmeijer E, Smit LA, de Boer JP, Navran A, Westerink B, de Koekkoek-Doll PK, Castelijns J, Wondergem M, Vogel WV, Kuijpers A, van Houdt WJ, Onderwater S, Maas-Bannink E, Cornelissen S, Broeks A, Tijink BM, Devriese LA, de Bree R, Blank CU, Schumacher TN, Thommen DS, Haanen JBAG, Zuur CL. Neoadjuvant ipilimumab and nivolumab in resectable cutaneous squamous cell carcinoma: a randomized phase 2 trial. Nat Med. 2025 Dec;31(12):4055-4064. doi: 10.1038/s41591-025-03943-w. Epub 2025 Oct 8. PubMed 41062829