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Clinical trial · no report yet · Phase 2
SAPHIRE
Hypofractionated vs. Conventional Regional Nodal Radiation Therapy for Patients With Invasive Breast Cancer
- NCT02912312 ↗
- Active, not recruiting
- M.D. Anderson Cancer Center
- Standard
We haven't built an HCP commentary report on SAPHIRE (Invasive Breast Carcinoma) yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.
Indexed commentary on SAPHIRE so far
Podcasts, YouTube videos and X posts we have indexed that name the trial. It is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this.
| Channel | Indexed | |
|---|---|---|
| YouTube | 7 | |
| Podcasts | 7 | |
| X threads | 7 |
The trial
ClinicalTrials.gov- Official title
- Shortening Adjuvant Photon Irradiation to Reduce Edema (SAPHIRE): A Randomized Trial of Hypofractionated Versus Conventionally Fractionated Regional Nodal Irradiation for Invasive Breast Cancer
- Phase
- Phase 2
- Status
- Active, not recruiting
- Conditions
- Invasive Breast Carcinoma; Stage I Breast Cancer AJCC v7; Stage IA Breast Cancer AJCC v7; Stage IB Breast Cancer AJCC v7; Stage II Breast Cancer AJCC v6 and v7; Stage IIA Breast Cancer AJCC v6 and v7; Stage IIB Breast Cancer AJCC v6 and v7; Stage IIIA Breast Cancer AJCC v7; Stage IIIC Breast Cancer AJCC v7
- Interventions
- Hypofractionated Radiation Therapy; Laboratory Biomarker Analysis; Quality-of-Life Assessment; Questionnaire Administration; Radiation Therapy
- Arms
- Arm I: Hypofractionated Regional Nodal Irradiation (RNI) · Experimental
- Arm II: Standard Regional Nodal Irradiation (RNI) · Active comparator
- Enrollment
- 805
- Primary outcomes
- Lymphedema rate as assessed by perometry
- Sponsor
- M.D. Anderson Cancer Center with National Cancer Institute (NCI)
- Start
- Feb 23, 2017
- Primary completion
- Feb 28, 2030 (estimated)
- Results posted
- No
- Registry record
- NCT02912312 · updated Jul 15, 2026
Publications
linked from the registry- Schaverien MV, Singh P, Kuerer HM, Akay CL, Chavez-MacGregor M, Chu CK, Clemens MW, Qiao W, Smith BD, Hoffman KE. Comparison of Outcomes of Microsurgical Breast Reconstruction after Premastectomy and Postmastectomy Radiation Therapy. J Am Coll Surg. 2025 Oct 1;241(4):535-549. doi: 10.1097/XCS.0000000000001444. Epub 2025 Sep 16. PubMed 40366003
- Schaverien MV, Singh P, Smith BD, Qiao W, Akay CL, Bloom ES, Chavez-MacGregor M, Chu CK, Clemens MW, Colen JS, Ehlers RA, Hwang RF, Joyner MM, Largo RD, Mericli AF, Mitchell MP, Shuck JW, Tamirisa N, Tripathy D, Villa MT, Woodward WA, Zacharia R, Kuerer HM, Hoffman KE. Premastectomy Radiotherapy and Immediate Breast Reconstruction: A Randomized Clinical Trial. JAMA Netw Open. 2024 Apr 1;7(4):e245217. doi: 10.1001/jamanetworkopen.2024.5217. PubMed 38578640