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Clinical trial · no report yet · Phase 2

NCT03410043

Osimertinib, Surgery, and Radiation Therapy in Treating Patients With Stage IIIB or IV Non-small Cell Lung Cancer With EGFR Mutations, NORTHSTAR Study

We haven't built a report for this trial yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.

Preliminary discovery

Commentary in our index that names this trial so far

Podcasts, YouTube videos and X posts we have indexed. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build.

ChannelFound
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The trial

ClinicalTrials.gov
Official title
Randomized Phase II Trial of Osimertinib With or Without Local Consolidation Therapy (LCT) for Patients With EGFR-Mutant Metastatic NSCLC (NORTHSTAR)
Phase
Phase 2
Status
Active, not recruiting
Conditions
Lung Non-Small Cell Carcinoma; Recurrent Lung Non-Small Cell Carcinoma; Stage IIIB Lung Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8
Interventions
Osimertinib; Radiation Therapy; Therapeutic Conventional Surgery
Arms
  • Group I (LCT) · Experimental
  • Group II (no LCT) · Experimental
Enrollment
173
Primary outcomes
  • Progression free survival (PFS)
Sponsor
M.D. Anderson Cancer Center with National Cancer Institute (NCI), National Comprehensive Cancer Network
Start
Jan 17, 2018
Primary completion
Apr 1, 2027 (estimated)
Results posted
No
Registry record
NCT03410043 · updated Sep 18, 2026