NCT04140487
Azacitidine, Venetoclax, and Gilteritinib in Treating Patients With Recurrent/Refractory FLT3-Mutated Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia, or High-Risk Myelodysplastic Syndrome/Myeloproliferative Neoplasm
- NCT04140487 ↗
- Recruiting
- M.D. Anderson Cancer Center
- Focused
We haven't built an HCP commentary report on NCT04140487 (gilteritinib plus azacitidine plus venetoclax in newly diagnosed or relapsed/refractory FLT3-mutated acute myeloid leukemia) yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.
Indexed commentary on NCT04140487 so far
Podcasts, YouTube videos and X posts we have indexed that name the trial. It is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this.
| Channel | Indexed | |
|---|---|---|
| X threads | 3 |
The trial
ClinicalTrials.gov- Official title
- A Phase I/II Study of Azacitidine, Venetoclax, and Gilteritinib for Patients With Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome With an Activating FLT3 Mutation
- Phase
- Phase 1/Phase 2
- Status
- Recruiting
- Conditions
- Recurrent Acute Myeloid Leukemia; Recurrent Chronic Myelomonocytic Leukemia; Recurrent Myelodysplastic/Myeloproliferative Neoplasm; Refractory Acute Myeloid Leukemia; Refractory Chronic Myelomonocytic Leukemia; Refractory Myelodysplastic/Myeloproliferative Neoplasm
- Interventions
- Azacitidine; Gilteritinib; Venetoclax
- Arms
- Treatment (azacitidine, venetoclax, gilteritinib) · Experimental
- Enrollment
- 97 (estimated)
- Primary outcomes
- Maximum-tolerated dose (MTD) of gilteritinib (Phase I)
- Overall response rate (OR) (Phase II)
- Sponsor
- M.D. Anderson Cancer Center
- Start
- Dec 17, 2019
- Primary completion
- Sep 1, 2028 (estimated)
- Results posted
- No
- Registry record
- NCT04140487 · updated Oct 6, 2026
Publications
linked from the registry- Short NJ, Kantarjian HM, Daver NG, Azevedo RS, Karrar O, DiNardo CD, Kadia TM, Yilmaz M, Maroun MM, Hachem MCR, Borthakur G, Issa GC, Shpall EJ, Popat UR, Huang X, Qiao W, Nasr LF, Macaron W, Abramova R, Garcia-Manero G, Konopleva M, Ravandi F. Long-Term Outcomes of Azacitidine, Venetoclax and Gilteritinib in Newly Diagnosed FLT3-Mutated AML. Blood Adv. 2026 May 27:bloodadvances.2026019841. doi: 10.1182/bloodadvances.2026019841. Online ahead of print. PubMed 42200455
- Short NJ, Daver N, Dinardo CD, Kadia T, Nasr LF, Macaron W, Yilmaz M, Borthakur G, Montalban-Bravo G, Garcia-Manero G, Issa GC, Chien KS, Jabbour E, Nasnas C, Huang X, Qiao W, Matthews J, Stojanik CJ, Patel KP, Abramova R, Thankachan J, Konopleva M, Kantarjian H, Ravandi F. Azacitidine, Venetoclax, and Gilteritinib in Newly Diagnosed and Relapsed or Refractory FLT3-Mutated AML. J Clin Oncol. 2024 May 1;42(13):1499-1508. doi: 10.1200/JCO.23.01911. Epub 2024 Jan 26. PubMed 38277619