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Clinical trial · no report yet · Phase 1/Phase 2
NCT05108870
TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers
- NCT05108870 ↗
- Active, not recruiting
- University of Chicago
- Focused
We haven't built an HCP commentary report on NCT05108870 (HB-201, HB-202 and 2 more in Human Papilloma Virus) yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.
Indexed commentary on NCT05108870 so far
Podcasts, YouTube videos and X posts we have indexed that name the trial. It is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this.
| Channel | Indexed | |
|---|---|---|
| YouTube | 2 | |
| Podcasts | 2 | |
| X threads | 2 |
The trial
ClinicalTrials.gov- Official title
- A Randomized Phase I/II Trial of TheraT® Vectors Expressing HPV16 Specific Antigens in Combination With Neoadjuvant Chemotherapy Followed by Transoral Robotic Surgery or Risk/Response Stratified Chemoradiotherapy for Locoregional HPV16+ Oropharyngeal Cancer
- Phase
- Phase 1/Phase 2
- Status
- Active, not recruiting
- Conditions
- Human Papilloma Virus; HPV; HPV Positive Oropharyngeal Squamous Cell Carcinoma; Head and Neck Cancer
- Interventions
- HB-201; HB-202; Carboplatin; Paclitaxel; Transoral Robotic Surgery
- Arms
- Phase 1: Dose-Finding Group 1 - Drug Combination 1 · Experimental
- Phase 1: Dose-Finding Group 2 - Drug Combination 2 · Experimental
- Phase 2: Efficacy Arm 1 - HB-201 + Chemotherapy · Experimental
- Phase 2: Efficacy Arm 2 - HB-201 and HB-202 + Chemotherapy · Experimental
- Enrollment
- 35
- Primary outcomes
- Phase 1 Primary Outcome: Phase 1 Dose of HB-201 and HB-201/202 Combined with Chemotherapy
- Phase 2 Primary Outcome: Deep Response Rate of Participants Treated with HB-201 or HB-201/202 Combined with Chemotherapy
- Sponsor
- University of Chicago
- Start
- Aug 22, 2022
- Primary completion
- Jan 1, 2027 (estimated)
- Results posted
- No
- Registry record
- NCT05108870 · updated Apr 24, 2026