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Clinical trial · no report yet · Phase 2

NCT06770582

Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial

We haven't built a report for this trial yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.

Preliminary discovery

Commentary in our index that names this trial so far

Podcasts, YouTube videos and X posts we have indexed. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build.

ChannelFound
X threads3
Bluesky threads1

The trial

ClinicalTrials.gov
Official title
Randomized Phase II Trial of Pembrolizumab and Radiation vs. Radiation and Concurrent Chemotherapy for High-Grade T1 Bladder Cancer (PARRC Trial)
Phase
Phase 2
Status
Recruiting
Conditions
Non-Muscle Invasive Bladder Urothelial Carcinoma; Recurrent Non-Muscle Invasive Bladder Urothelial Carcinoma; Stage I Bladder Cancer AJCC v8
Interventions
Biospecimen Collection; Cisplatin; Computed Tomography; Fluorouracil; Gemcitabine; Magnetic Resonance Imaging; Mitomycin; Pembrolizumab; Questionnaire Administration; Radiation Therapy
Arms
  • Arm 1 (Chemotherapy and radiation) · Active comparator
  • Arm 2 (Pembrolizumab and radiation) · Experimental
Enrollment
160 (estimated)
Primary outcomes
  • Bladder intact event-free survival (BIEFS)
  • Global quality of life
Sponsor
National Cancer Institute (NCI)
Start
Jun 3, 2025
Primary completion
Feb 1, 2032 (estimated)
Results posted
No
Registry record
NCT06770582 · updated Oct 19, 2026