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Clinical trial · no report yet · Phase 2
OUTRUN
A Randomised Phase II Trial of Osimertinib With or Without SRS for EGFR Mutated NSCLC With Brain Metastases
- NCT03497767 ↗
- Completed
- Trans Tasman Radiation Oncology Group
- Focused
We haven't built an HCP commentary report on OUTRUN (osimertinib plus stereotactic radiosurgery; osimertinib in EGFR-mutated NSCLC with brain metastases) yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.
Indexed commentary on OUTRUN so far
Podcasts, YouTube videos and X posts we have indexed that name the trial. It is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this.
| Channel | Indexed | |
|---|---|---|
| X threads | 7 | |
| Podcasts | 1 |
The trial
ClinicalTrials.gov- Official title
- A Randomised Phase II Trial of Osimertinib With or Without Stereotactic Radiosurgery for EGFR Mutated Non-Small Cell Lung Cancer (NSCLC) With Brain Metastases
- Phase
- Phase 2
- Status
- Completed
- Conditions
- Metastatic Non Small Cell Lung Cancer
- Interventions
- Osimertinib; Stereotactic Radiosurgery (SRS)
- Arms
- Osimertinib · Experimental
- Stereotactic Radiosurgery + Osimertinib · Experimental
- Enrollment
- 40
- Primary outcomes
- Intracranial progression free survival at 12 months
- Sponsor
- Trans Tasman Radiation Oncology Group
- Start
- Aug 15, 2019
- Primary completion
- Apr 30, 2024
- Results posted
- No
- Registry record
- NCT03497767 · updated May 31, 2024
Publications
linked from the registry- Lee CK, Lefresne S, Soon YY, Robledo K, Nichol A, Sahgal A, Pinkham MB, Melosky B, Huang Y, McDermott R, Tham IWK, Parmar A, Tey JCS, Liu M, Solomon BJ, Sacher A, Leong CN, Laskin J, Koh WY, Menjak IB, Ang Y, Shultz DB, Low JL, Doherty M, Yong C, Lim MC, Tan AP, Soo RA, Hegi-Johnson F, Ho C. Osimertinib and Stereotactic Radiosurgery for Brain Metastases in EGFR-Mutated Lung Cancer: The STARLET Joint Analysis of OUTRUN and LUOSICNS Randomized Trials. J Thorac Oncol. 2026 May;21(5):103549. doi: 10.1016/j.jtho.2026.01.001. Epub 2026 Jan 12. PubMed 41534788