Clinical trial · no report yet · Phase 3
PATHOS
Post-operative Adjuvant Treatment for HPV-positive Tumours (PATHOS)
- NCT02215265 ↗
- Active, not recruiting
- Lisette Nixon
- Standard
We haven't built a report for this trial yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.
Preliminary discovery
Commentary in our index that names this trial so far
Podcasts, YouTube videos and X posts we have indexed. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build.
| Channel | Found | |
|---|---|---|
| X threads | 11 | |
| Podcasts | 2 | |
| YouTube | 1 |
The trial
ClinicalTrials.gov- Official title
- A Phase III Trial of Risk-stratified, Reduced Intensity Adjuvant Treatment in Patients Undergoing Transoral Surgery for Human Papillomavirus (HPV)-Positive Oropharyngeal Cancer
- Phase
- Phase 3
- Status
- Active, not recruiting
- Conditions
- Human Papillomavirus (HPV)-Positive Oropharyngeal Cancer
- Interventions
- Cisplatin; Postoperative radiotherapy
- Arms
- A: No adjuvant treatment · No intervention
- B1: Postoperative radiotherapy 60 Gray · Active comparator
- B2: Postoperative radiotherapy 50 Gray · Experimental
- C1: Postoperative radiotherapy 60 Gray with Cisplatin · Active comparator
- C2: Postoperative radiotherapy 60 Gray without chemotherapy · Experimental
- Enrollment
- 1,269 (estimated)
- Primary outcomes
- MDADI/Overall survival co-primary endpoint
- Sponsor
- Lisette Nixon with UNICANCER, AdventHealth, University of Leipzig, Princess Alexandra Hospital, Brisbane, Australia, Stanford University
- Start
- Oct 2015
- Primary completion
- Oct 2027 (estimated)
- Results posted
- No
- Registry record
- NCT02215265 · updated Feb 19, 2025
Publications
linked from the registry- O'Hara JT, Hurt CN, Ingarfield K, Patterson JM, Hutcheson K, Canham JE, Nixon LS, Heiberg CD, Johson S, Evans M, Jones TM. Transoral Laser or Robotic Surgery Outcomes for Oropharyngeal Carcinoma: Secondary Analysis of the PATHOS Randomized Clinical Trial. JAMA Otolaryngol Head Neck Surg. 2024 Oct 10;150(11):1002-11. doi: 10.1001/jamaoto.2024.3371. Online ahead of print. PubMed 39388196
- Owadally W, Hurt C, Timmins H, Parsons E, Townsend S, Patterson J, Hutcheson K, Powell N, Beasley M, Palaniappan N, Robinson M, Jones TM, Evans M. PATHOS: a phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV) positive oropharyngeal cancer. BMC Cancer. 2015 Aug 27;15:602. doi: 10.1186/s12885-015-1598-x. PubMed 26311526