Clinical trial · no report yet · Phase 2/Phase 3
PSMAcTION
Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy
- NCT06780670 ↗
- Recruiting
- Novartis Pharmaceuticals
- Standard
We haven't built a report for this trial yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.
Preliminary discovery
Commentary in our index that names this trial so far
Podcasts, YouTube videos and X posts we have indexed. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build.
| Channel | Found | |
|---|---|---|
| X threads | 8 | |
| YouTube | 4 | |
| Podcasts | 2 |
The trial
ClinicalTrials.gov- Official title
- PSMAcTION: A Phase II/III, Open-label, International, Multicenter, Randomized Study of AAA817 Versus Standard of Care in the Treatment of Adult Participants With PSMA Positive Metastatic Castration-resistant Prostate Cancer Who Progressed on or After [177Lu]Lu-PSMA Targeted Therapy
- Phase
- Phase 2/Phase 3
- Status
- Recruiting
- Conditions
- Prostate Cancer
- Interventions
- Investigators choice of SoC; AAA817; AAA817; AAA817
- Arms
- Phase II: AAA817 Dose B · Experimental
- Phase III: Investigator's choice of SoC · Active comparator
- Phase II: AAA817 Dose A · Experimental
- Phase III: Recommended Phase 3 Dose of AAA817 · Experimental
- Enrollment
- 443 (estimated)
- Primary outcomes
- Biochemical response rate (Phase II)
- Adverse Events (AEs) and Serious Adverse Events (SAEs), and deaths - Phase II
- Tolerability of the proposed dose of AAA817- Phase II
- Radiographic progression-free survival (rPFS)- Phase III
- Overall survival (OS)- Phase III
- Sponsor
- Novartis Pharmaceuticals
- Start
- Feb 27, 2025
- Primary completion
- Jun 27, 2028 (estimated)
- Results posted
- No
- Registry record
- NCT06780670 · updated Sep 22, 2026