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Clinical trial · no report yet · Phase 2
Restore-PV
A Phase 2, Open-Label Study of DISC-3405 in Participants With Polycythemia Vera (PV)
- NCT06985147 ↗
- Active, not recruiting
- Disc Medicine, Inc
- Focused
We haven't built an HCP commentary report on Restore-PV (DISC-3405 in Polycythemia Vera (PV)) yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.
Indexed commentary on Restore-PV so far
Podcasts, YouTube videos and X posts we have indexed that name the trial. It is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this.
| Channel | Indexed | |
|---|---|---|
| X threads | 4 | |
| YouTube | 1 |
The trial
ClinicalTrials.gov- Official title
- A Phase 2, Open-Label Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of DISC-3405 in Participants With Polycythemia Vera (PV)
- Phase
- Phase 2
- Status
- Active, not recruiting
- Conditions
- Polycythemia Vera (PV)
- Interventions
- DISC-3405
- Arms
- Within-participant dose escalation · Experimental
- Enrollment
- 60 (estimated)
- Primary outcomes
- Number of participants with treatment-related adverse events as assessed by CTCAE
- Incidence of clinically abnormal vital signs
- Incidence of clinically abnormal physical exam
- Incidence of clinically abnormal electrocardiograms
- Incidence of abnormal laboratory test results
- Sponsor
- Disc Medicine, Inc
- Start
- Aug 12, 2025
- Primary completion
- Feb 2027 (estimated)
- Results posted
- No
- Registry record
- NCT06985147 · updated Jul 31, 2026