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Clinical trial · no report yet · Phase 2
STELLAR
A Trial of CHOP-R Therapy, With or Without Acalabrutinib, in Patients With Newly Diagnosed Richter's Syndrome
- NCT03899337 ↗
- Active, not recruiting
- University of Birmingham
- Focused
We haven't built an HCP commentary report on STELLAR (acalabrutinib in Richter's syndrome) yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.
Indexed commentary on STELLAR so far
Podcasts, YouTube videos and X posts we have indexed that name the trial. It is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this.
| Channel | Indexed | |
|---|---|---|
| X threads | 3 |
The trial
ClinicalTrials.gov- Official title
- A Phase II, Randomised Study of CHOP-R in Combination With Acalabrutinib Compared to CHOP-R in Patients With Newly Diagnosed Richter's Syndrome and a Platform for Initial Investigations Into Activity of Novel Treatments in Relapsed/Refractory and Newly Diagnosed Richter's Syndrome.
- Phase
- Phase 2
- Status
- Active, not recruiting
- Conditions
- Richter Syndrome
- Interventions
- Acalabrutinib; Cyclophosphamide; Doxorubicin; Vincristine; Prednisolone; Rituximab
- Arms
- Standard of Care Arm (CHOP-R) · Active comparator
- Experimental Arm (CHOP-R + Acalabrutinib) · Experimental
- Cohort 1 - Acalabrutinib Monotherapy - Platform Trial · Experimental
- Cohort 2 - CHOP-R + Acalabrutinib - Platform Trial · Experimental
- Enrollment
- 72
- Primary outcomes
- Randomised Component - Progression free survival (PFS)
- Registration Arm - Cohort 1 - Overall Response
- Registration Arm - Cohort 2 - Overall Response
- Sponsor
- University of Birmingham with Bloodwise, AstraZeneca
- Start
- Jul 23, 2019
- Primary completion
- Jun 30, 2028 (estimated)
- Results posted
- No
- Registry record
- NCT03899337 · updated Aug 7, 2026
Publications
linked from the registry- Appleby N, Eyre TA, Cabes M, Jackson A, Boucher R, Yates F, Fox S, Rawstron A, Hillmen P, Schuh A. The STELLAR trial protocol: a prospective multicentre trial for Richter's syndrome consisting of a randomised trial investigation CHOP-R with or without acalabrutinib for newly diagnosed RS and a single-arm platform study for evaluation of novel agents in relapsed disease. BMC Cancer. 2019 May 20;19(1):471. doi: 10.1186/s12885-019-5717-y. PubMed 31109313
- Klintman J, Appleby N, Stamatopoulos B, Ridout K, Eyre TA, Robbe P, Pascua LL, Knight SJL, Dreau H, Cabes M, Popitsch N, Ehinger M, Martin-Subero JI, Campo E, Mansson R, Rossi D, Taylor JC, Vavoulis DV, Schuh A. Genomic and transcriptomic correlates of Richter transformation in chronic lymphocytic leukemia. Blood. 2021 May 20;137(20):2800-2816. doi: 10.1182/blood.2020005650. PubMed 33206936