ZUMA-7

Podcasts, YouTube videos and X posts in our index that name this trial. A report screens them, searches for more and cites what clinicians said when it is built.

Official title

A Phase 3, Randomized, Open-Label Study Evaluating the Efficacy of Axicabtagene Ciloleucel Versus Standard of Care Therapy in Subjects With Relapsed/Refractory Diffuse Large B Cell Lymphoma (ZUMA-7)

Phase

Phase 3

Status

Completed

Conditions

Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)

Interventions

Axicabtagene Ciloleucel; Platinum-containing Salvage Chemotherapy; Cyclophosphamide; Fludarabine

Arms

• Axicabtagene Ciloleucel Treatment · Experimental
• Standard of Care Therapy · Active comparator

Enrollment

359

Primary outcomes

• Event Free Survival (EFS) Per Blinded Central Assessment

Sponsor

Kite, A Gilead Company

Start

Jan 25, 2018

Primary completion

Mar 18, 2021

Results posted

Yes

Registry record

NCT03391466 · updated Dec 1, 2025

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• Kersten MJ, Qiao Y, Shah R, Solem C, Snider JT, To C, Cheng P, Spooner C, Perales MA. Quality-Adjusted Time without Symptoms or Toxicity: Analysis of Axicabtagene Ciloleucel versus Standard of Care in Patients with Relapsed/Refractory Large B Cell Lymphoma. Transplant Cell Ther. 2023 May;29(5):335.e1-335.e8. doi: 10.1016/j.jtct.2023.01.008. Epub 2023 Jan 14. PubMed 36646322
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• Ghobadi A, Munoz J, Westin J, Locke FL, Miklos DB, Rapoport AP, et al. Outcomes of Subsequent Anti-Lymphoma Therapies in Patients (Pts) with Large B-Cell Lymphoma (LBCL) Treated with Axicabtagene Ciloleucel (Axi-Cel) or Standard of Care (SOC) in the Second-Line (2L) ZUMA-7 Study. Blood. 2022;140(Supplement 1):1595-1597.
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