Clinical trial · no report yet · Phase 2
FMT-LUMINATE
Fecal Microbial Transplantation Non-Small Cell Lung Cancer and Melanoma
- NCT04951583 ↗
- Unknown
- Centre hospitalier de l'Université de Montréal (CHUM)
- Standard
We haven't built a report for this trial yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.
Preliminary discovery
Commentary in our index that names this trial so far
Podcasts, YouTube videos and X posts we have indexed. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build.
| Channel | Found | |
|---|---|---|
| X threads | 11 | |
| Podcasts | 2 | |
| Bluesky threads | 1 |
The trial
ClinicalTrials.gov- Official title
- Phase II Trial of Fecal Microbial Transplantation in Patients With Advanced Non-Small Cell Lung Cancer and Melanoma Treated With Immune Checkpoint Inhibitors.
- Phase
- Phase 2
- Status
- Unknown
- Conditions
- Non Small Cell Lung Cancer Metastatic; Advanced Melanoma
- Interventions
- FMT + ICI
- Arms
- Immune checkpoint inhibitor (ICI) therapy in combination with fecal microbial transplantation (FMT). · Experimental
- Enrollment
- 45
- Primary outcomes
- Objective response rate in the NSCLC cohort by RECIST criteria.
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
- Start
- Nov 16, 2021
- Primary completion
- Sep 1, 2024 (estimated)
- Results posted
- No
- Registry record
- NCT04951583 · updated Aug 7, 2024
Publications
linked from the registry- Duttagupta S, Messaoudene M, Hunter S, Desilets A, Jamal R, Mihalcioiu C, Belkaid W, Marcoux N, Fidelle M, Suissa D, Ponce M, Geiger M, Malo J, Piccinno G, Puncochar M, Filin A, Heidrich V, Rusu D, Mbaye B, Durand S, Ben Aissa I, Puller V, de Lahondes R, Blais N, Tehfe M, Owen S, Belanger K, Parvathy SN, Shieh B, Raphael J, Lenehan J, Breadner D, Rothenstein J, Rozza N, Maillou J, Nili S, Prifti DK, Pinto F, Armanini F, Kim-Schulze S, Marron TU, Kroemer G, Derosa L, Zitvogel L, Silverman M, Segata N, Maleki Vareki S, Routy B, Elkrief A. Fecal microbiota transplantation plus immunotherapy in non-small cell lung cancer and melanoma: the phase 2 FMT-LUMINate trial. Nat Med. 2026 Apr;32(4):1337-1350. doi: 10.1038/s41591-025-04186-5. Epub 2026 Jan 28. PubMed 41606121