Erudio Healtherudio.com
Clinical trial · no report yet · Phase 1
NCT04573140 trial: what clinicians have said so far
A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)
- NCT04573140 ↗
- Recruiting
- University of Florida
- Focused size, estimated: 1–150 verified statements
We haven't built an HCP commentary report on NCT04573140 yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.
Indexed commentary on NCT04573140 so far
Podcasts, YouTube videos and X posts we have indexed that name the trial. It is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this.
| Indexed so far | |
|---|---|
| 2 posts on X | |
| 1 post on Bluesky |
The trial
ClinicalTrials.gov- Official title
- A Phase I/II Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM), and Recurrent/Progressive Medulloblastoma (MB)
- Phase
- Phase 1
- Status
- Recruiting
- Conditions
- Adult Glioblastoma; High Grade Glioma; WHO Grade III or IV Malignant Glioma
- Interventions
- Autologous total tumor mRNA and pp65 full length (fl) lysosomal associated membrane protein (LAMP) mRNA loaded DOTAP liposome vaccine administered intravenously (RNA loaded lipid particles, RNA-LPs)
- Arms
- Adult GBM (Stratum 1) · Experimental
- Pediatric HGG (Stratum 2) · Experimental
- Enrollment
- 28 (estimated)
- Primary outcomes
- Manufacturing feasibility
- Safety of RNA-LP vaccine
- Determination of Maximum Tolerated Dose
- Sponsor
- University of Florida with Pediatric Neuro-Oncology Consortium, University of California, San Francisco, CureSearch, Team Jack Foundation, Florida Department of Health, Food and Drug Administration (FDA)
- Start
- Dec 13, 2021
- Primary completion
- Jul 1, 2027 (estimated)
- Results posted
- No
- Registry record
- NCT04573140 · updated Oct 30, 2026
Publications
linked from the registry- Carrera-Justiz S, Aghaee M, Qdaisat S, Weidert F, Garcia GA, Fagman L, Zhang D, Stover B, Moor RSF, Xie C, Goldenberg E, von Roemeling C, Doonan B, Chardon-Robles J, Elliott L, Sawyer WG, Deleyrolle LP, Sahay B, Foster TP, Seligson ND, Rahman M, Ghiaseddin A, Castillo P, Lee JH, Silver NL, Doty A, Ligon JA, Milner RJ, Mitchell D, Mendez-Gomez H, Moore H, Sayour EJ. Systemic mRNA vaccines elicit rapid immune activation in canine brain tumors. J Immunother Cancer. 2025 Nov 11;13(11):e011817. doi: 10.1136/jitc-2025-011817. PubMed 41218853
- Melnick K, Dastmalchi F, Mitchell D, Rahman M, Sayour EJ. Contemporary RNA Therapeutics for Glioblastoma. Neuromolecular Med. 2022 Mar;24(1):8-12. doi: 10.1007/s12017-021-08669-9. Epub 2021 Jun 8. PubMed 34101090