Clinical trial · no report yet · Phase 2
PEMBRO-RT
Pembrolizumab After SBRT Versus Pembrolizumab Alone in Advanced NSCLC
- NCT02492568 ↗
- Completed
- The Netherlands Cancer Institute
- Focused
We haven't built a report for this trial yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.
Preliminary discovery
Commentary in our index that names this trial so far
Podcasts, YouTube videos and X posts we have indexed. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build.
| Channel | Found | |
|---|---|---|
| X threads | 3 |
The trial
ClinicalTrials.gov- Official title
- Randomized Phase II, 2-arm Study of Pembrolizumab After High Dose Radiation (SBRT) Versus Pembrolizumab Alone in Patients With Advanced Non-small Cell Lung Cancer
- Phase
- Phase 2
- Status
- Completed
- Conditions
- Non-Small Cell Lung Cancer
- Interventions
- pembrolizumab; Stereotactic Body Radiation Therapy
- Arms
- SBRT + Pembrolizumab · Experimental
- Pembrolizumab alone · Active comparator
- Enrollment
- 92
- Primary outcomes
- Overall Response Rate
- Sponsor
- The Netherlands Cancer Institute with Merck Sharp & Dohme LLC
- Start
- Jul 2015
- Primary completion
- Jun 2018
- Results posted
- No
- Registry record
- NCT02492568 · updated Aug 17, 2020
Publications
linked from the registry- Theelen WSME, Chen D, Verma V, Hobbs BP, Peulen HMU, Aerts JGJV, Bahce I, Niemeijer ALN, Chang JY, de Groot PM, Nguyen QN, Comeaux NI, Simon GR, Skoulidis F, Lin SH, He K, Patel R, Heymach J, Baas P, Welsh JW. Pembrolizumab with or without radiotherapy for metastatic non-small-cell lung cancer: a pooled analysis of two randomised trials. Lancet Respir Med. 2021 May;9(5):467-475. doi: 10.1016/S2213-2600(20)30391-X. Epub 2020 Oct 20. PubMed 33096027
- Theelen WSME, Peulen HMU, Lalezari F, van der Noort V, de Vries JF, Aerts JGJV, Dumoulin DW, Bahce I, Niemeijer AN, de Langen AJ, Monkhorst K, Baas P. Effect of Pembrolizumab After Stereotactic Body Radiotherapy vs Pembrolizumab Alone on Tumor Response in Patients With Advanced Non-Small Cell Lung Cancer: Results of the PEMBRO-RT Phase 2 Randomized Clinical Trial. JAMA Oncol. 2019 Sep 1;5(9):1276-1282. doi: 10.1001/jamaoncol.2019.1478. PubMed 31294749