Clinical trial · no report yet · Phase not applicable

SMART ONE trial: what clinicians have said so far

Stereotactic MRI-guided Adaptive Radiation Therapy (SMART) in One Fraction

NCT04939246 ↗
Completed
Baptist Health South Florida
Focused size, estimated: 1–150 verified statements once built

We haven't built an HCP commentary report on SMART ONE (inoperable primary or metastatic carcinoma; tests a strategy, not a drug) yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.

Indexed commentary on SMART ONE so far

Podcasts, YouTube videos and X posts we have indexed that name the trial. It is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this.

Indexed so far
9 posts on X, typically up to 40 once built

Indexed todayTypical once built

The trial

ClinicalTrials.gov

Official title: A Feasibility Study of Stereotactic MRI-guided Adaptive Radiation Therapy (SMART) in One Fraction for Inoperable Primary or Metastatic Carcinoma (SMART ONE)
Phase: Phase not applicable
Status: Completed
Conditions: Metastatic Carcinoma
Interventions: Stereotactic ablative body radiation therapy
Arms: Single-fraction SABR · Other
Enrollment: 30
Primary outcomes: Number of Participants With SABR Successfully Delivered in One Fraction
Number of Patients Demonstrating Tolerability
Sponsor: Baptist Health South Florida with Viewray Inc.
Start: Jun 18, 2021
Primary completion: Jul 17, 2024
Results posted: Yes
Registry record: NCT04939246 · updated Jul 17, 2025

Publications

linked from the registry

Chuong MD, Mittauer KE, Bassetti MF, Rojas C, Glide-Hurst C, Kalman NS, Tom MC, Rubens M, Crosby J, Burr A, Tolakanahalli R, Gutierrez AN, Bassiri N, Mehta MP, Kotecha R. Stereotactic Magnetic Resonance Guided Adaptive Radiation Therapy in One Fraction (SMART ONE): A Multicenter, Single-Arm, Phase 2 Trial. Int J Radiat Oncol Biol Phys. 2025 Jul 15;122(4):957-967. doi: 10.1016/j.ijrobp.2025.03.030. Epub 2025 Mar 28. PubMed 40158734

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