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Clinical trial · no report yet · Phase 3

STELLAR-304

Study of XL092 + Nivolumab vs Sunitinib in Subjects With Advanced or Metastatic Non-Clear Cell Renal Cell Carcinoma

  • NCT05678673 ↗
  • Active not recruiting
  • Exelixis
  • 60 commentary sources found
  • Deep

We haven't built a report for this trial yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.

Commentary we found

Podcasts, YouTube videos and X posts in our index that name this trial. A report screens them, searches for more and cites what clinicians said when it is built.

ChannelFound
YouTube22
X threads21
Podcasts15
X videos2

The trial

ClinicalTrials.gov
Official title
A Randomized Open-Label Phase 3 Study of XL092 + Nivolumab vs Sunitinib in Subjects With Advanced or Metastatic Non-Clear Cell Renal Cell Carcinoma
Phase
Phase 3
Status
Active not recruiting
Conditions
Non-Clear Cell Renal Cell Carcinoma
Interventions
XL092; Nivolumab; Sunitinib Malate
Arms
  • XL092 + Nivolumab · Experimental
  • Sunitinib Malate · Active comparator
Enrollment
317
Primary outcomes
  • Duration of Progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1), by Blinded Independent Radiology Committee (BIRC)
  • Objective response rate (ORR) as assessed by BIRC per RECIST 1.1
Sponsor
Exelixis
Start
Jan 1, 2023
Primary completion
Dec 15, 2026 (estimated)
Results posted
No
Registry record
NCT05678673 · updated Jul 29, 2026

Publications

linked from the registry
  • Pal SK, Powles T, Kanesvaran R, Molina-Cerrillo J, Feldman DR, Barata P, Liu M, Bhatt A, Wang Z, Nandoskar P, Suarez C. STELLAR-304: a phase III study of zanzalintinib (XL092) plus nivolumab in advanced non-clear cell renal cell carcinoma. Future Oncol. 2025 Mar;21(7):787-794. doi: 10.1080/14796694.2025.2458395. Epub 2025 Feb 26. PubMed 40008409