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Clinical trial · no report yet · Phase 3

LAP100

Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

We haven't built a report for this trial yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.

Commentary we found

Podcasts, YouTube videos and X posts in our index that name this trial. A report screens them, searches for more and cites what clinicians said when it is built.

ChannelFound
X threads56
X videos8
YouTube4
Podcasts1

The trial

ClinicalTrials.gov
Official title
A Phase III Randomized Trial of Dose Escalated Radiation in Locally Advanced Pancreas Cancer (LAPC) Patients (LAP100)
Phase
Phase 3
Status
Recruiting
Conditions
Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma; Stage II Pancreatic Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8
Interventions
Biopsy Procedure; Biospecimen Collection; Capecitabine; Computed Tomography; Dose-escalated Radiation Therapy; Fluorouracil; Gemcitabine; Irinotecan Hydrochloride; Irinotecan Sucrosofate; Leucovorin Calcium; Magnetic Resonance Imaging; Nab-paclitaxel; Observation Activity; Oxaliplatin; Positron Emission Tomography; Questionnaire Administration; Radiation Therapy; Tumor Treating Fields Therapy
Arms
  • Arm I (Options 1, 2, or 3) · Active comparator
  • Arm II (dose-escalated RT) · Experimental
Enrollment
356 (estimated)
Primary outcomes
  • Overall survival (OS)
Sponsor
NRG Oncology
Start
Aug 21, 2025
Primary completion
Oct 21, 2030 (estimated)
Results posted
No
Registry record
NCT06958328 · updated Aug 25, 2026