Clinical trial · no report yet · Phase 3
RASolute 305
Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of Investigator's Choice as First-line Treatment in Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma ( RASolute 305 )
- NCT07621718 ↗
- Recruiting
- Revolution Medicines, Inc.
- Standard
We haven't built a report for this trial yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.
Preliminary discovery
Commentary in our index that names this trial so far
Podcasts, YouTube videos and X posts we have indexed. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build.
| Channel | Found | |
|---|---|---|
| X threads | 10 | |
| YouTube | 3 | |
| Podcasts | 1 |
The trial
ClinicalTrials.gov- Official title
- RASolute 305: A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Investigator Choice of Chemotherapy (Modified FOLFIRINOX or Gemcitabine Plus Nab-Paclitaxel) With or Without Zoldonrasib (RMC-9805) as First-line Treatment in Patients With Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma
- Phase
- Phase 3
- Status
- Recruiting
- Conditions
- Pancreatic Cancer; Pancreatic Cancer Metastatic; PDAC; PDAC - Pancreatic Ductal Adenocarcinoma; Pancreatic Ductal Adenocarcinoma (PDAC); Pancreatic Adenocarcinoma Metastatic; Pancreatic Adenocarcinoma; Pancreatic Adenosquamous Carcinoma
- Interventions
- Zoldonrasib; Placebo; Oxaliplatin; Leucovorin (Calcium Folinate); 5-Fluorouracil; Irinotecan; Gemcitabine (GEM); Nab-paclitaxel
- Arms
- Arm A: zoldonrasib + chemotherapy · Experimental
- Arm B: placebo + chemotherapy · Placebo comparator
- Enrollment
- 670 (estimated)
- Primary outcomes
- Progression free survival (PFS)
- Overall survival (OS)
- Sponsor
- Revolution Medicines, Inc.
- Start
- May 22, 2026
- Primary completion
- Dec 30, 2028 (estimated)
- Results posted
- No
- Registry record
- NCT07621718 · updated Oct 13, 2026